University of Sheffield, 29-31 July 1998

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Provisional Programme


The Hopkins Medal Lecture was given by Professor Darwin Prockop
Pleasant surprises en route from the Biochemistry of collagen to gene therapy
The Novartis Medal Lecture was given by Professor Richard Perham

Wednesday 29 July/ Thursday 30 July/ Friday 31 July

Inaugural Symposium for the Developmental Genetics Programme, Krebs Institute, Sheffield

http://www.shef.ac.uk/uni/academic/A-C/biomsc/research/dgp.html

Host Colloquium:
Cellular Basis of Development

Sponsors:
Pfizer Animal Health
Ontogeny Inc.
Smith Kline Beecham
Unilever
The Company of Biologists
Merck Sharpe and Dohme
Current Biology Ltd.
Organiser:
P. Ingham (Sheffield)

Wednesday 29th July

Speakers:
09.00 L. Robertson (Harvard)
Title to be confirmed
09.40 E. Knust (D�sseldorf)
Control of cell polarity in Drosophila
10.20 M. Peifer (Chapel Hill)
Cell adhesion, signal transduction and cancer: the Armadillo connection
11.00 Coffee
11.20 T. Schupbach (Princeton)
Intercellular signalling and dorsoventral pattern formation in Drosophila oogenesis
12.00 B. Shilo (Rehovot)
Branching morphogenesis in the Drosophila tracheal system
12.40 Lunch
14.00 R. Treisman (ICRF, London)
Rho-family GTPases and the serum response element
14.20 J. Williams (London)
A family of STAT proteins that regulate cellular differentiation in Dictyostelium
15.20 N. Perrimon (Harvard)
Mechanisms involved in the long range diffusion of Wnt and Hedgehog morphogens
16.00 Poster Session

Thursday 30th July

09.00 M. Leptin (Cologne)
Gastrulation in Drosophila: The logic and the nuts and bolts
09.40 P. Simpson (Strasbourg)
Notch signalling and the origin of spaced bristle patterns in insects
10.20 G. Morata (Madrid)
exd function, Dpp/Wg signalling and limb development
11.00 Coffee
11.20 C. Tabin (Harvard)
Signals patterning the vertebrate limb
12.00 N. Hastie (Edinburgh)
12.40 Lunch
13.40 R. Harland (Berkeley)
BMP antagonists in vertebrate development
14.20 H. J�ckle (G�ttingen)
Title to be confirmed
15.00 K. Anderson (New York)
Patterning the mouse embryo: perspectives from new mutations
15.40 M. Bronner-Fraser (Caltech)
Formation of the neural crest
16.20 Poster Session

Friday 31st July

08.40 P. Cohen (Dundee)
Dissection of the PDK-PKB-GSK3 cascade and its role in insulin signal transduction and apoptosis
09.20 R. Nusse (Stanford)
Signalling by Wnt genes during Drosophila development
10.00 Poster Session
11.00 A. McMahon (Harvard)
Cell interactions regulating growth and pattern in the vertebrate embryo
11.40 R. Lehmann (New York)
Germ cell migration in Drosophila
12.20 C. Desplan (New York)
Rhodopsin expression in R7 and R8 cells: a plastic system for detecting colour and polarised light in insects
13.00 Lunch
14.00 C. Kimmel (Oregon)
14.40 E. Wieschaus (Princeton)
15.20 S. Fraser (Caltech)

Wednesday 29 July/ Thursday 30 July/ Friday 31 July

Annual Symposium:
Mitochondria and Cell Death

Sponsors:
SmithKline Beecham
Merck Sharpe Dohme
Glaxo Wellcome
Pfizer
Janssen
Organisers:
G. Brown (Cambridge, UK)
D. Nicholls (Dundee)
C. Cooper (Essex)

Wednesday 29 July

Speakers:
09.00 Introduction
09.10 G. Kroemer (Villejuif)
Mitochondrial control of apoptosis
09.50 X. Wang (Atlanta)
Apoptosis and cytochrome c
10.30 Coffee
11.00 G. Brown (Cambridge, UK)
Nitric oxide, cytochrome c and mitochondria
11.40 S. Moncada (London)
Persistent inhibition of cell respiration by nitric oxide; role of S-nitrosylation and protection by glutathione
12.20 General discussion
12.30 Lunch
13.30 C. Richter (Zurich)
Nitric oxide, apoptosis, DNA and mitochondrial calcium
14.10 A. Murphy (San Diego)
Bcl-2 and mitochondrial cytochrome c release in neural cell apoptosis
14.50 M. Beal (Harvard)
Mitochondria, nitric oxide and neurodegeneration
15.30 H. Mehmet (London)
Maple syrup urine disease metabolites induce apoptosis in neural cells without cytochrome c release or changes in mitochondrial membrane potential
15.50 General discussion
16.00 Poster Session

Thursday 30 July

09.00 D. Nicholls (Dundee)
Excitotoxicity and mitochondria
09.40 P. Nicotera (Konstanz)
Calcineurin and mitochondrial function in neuronal cell death
10.20 Coffee
10.50 J. Dubinsky (Minnesota)
Mitochondrial permeability transition pore and astrocytes
11.30 S. Heales (London)
Glutathione, nitric oxide and mitochondrial damage
11.50 P. Brookes (London)
Peroxynitrate increases brain mitochondrial proton leak
12.05 G. Fletcher (Cambridge)
Cytochrome c release and apoptosis in neural cells
12.20 General discussion
12.30 Lunch
13.30 J. Greenamyre (New York)
Glutamate and Parkinson's Disease
14.10 A. Schapira (London)
Mitochondrial DNA in neurodegeneration
14.50 S. Rothman (St. Louis)
Disorders to the mitochondrial genome
15.30 P. Hartfield (Flinders)
The role of JNK in ceramide-induced apoptosis in PC12 cells
15.50 General discussion
16.00 Poster Session

Friday 31 July

Speakers:
09.00 C. Cooper (Essex)
Mitochondria, apoptosis and hypoxic-ischaemic damage to the new-born human brain
09.40 G. Jones (London)
Coagulative necrosis: the forgotten way to die
10.00 Poster Session
11.00 R. Hansford (Baltimore)
Mitochondria in heart ischaemia and ageing
11.40 M. Singer (London)
Mitochondrial dysfunction in sepsis
12.20 General discussion
12.30 Lunch
13.30 M. Crompton (London)
Calcium, oxidant stress and mitochondrial function
14.10 E. Ledgerwood (Cambridge)
Tumour necrosis factor is trafficked to a mitochondrial TNF binding protein
14.30 A. Halestrap (Bristol)
The permeability transition pore
15.10 J. Lemasters (Chapel Hill)
Confocal microscopy of the permeability transition in cell injury
15.50 General discussion
16.00 End

Wednesday 29 July

Biochemical Immunology Group:
Phagocyte Recognition of Dead and Dying Cells

Organisers:
I. Dransfield (Edinburgh)
C. Gregory (Nottingham)
Speakers:
09.00 J. Savill (Nottingham)
Overview and recent developments in phagocyte recognition of apoptotic and post-apoptotic cells.
09.40 G. Chimini (Marseille)
The ATP binding cassette transporter and the phagocytosis apoptotic cells
10.20 L. Dini (Rome)
Kupfer cells and phagocytosis of apoptotic bodies in the liver
11.00 Coffee
11.20 N. Platt (Oxford)
Role of scavenger receptors in clearance of apoptotic thymocytes
12.00 C. Gregory (Nottingham)
Macrophage phagocytosis of apoptotic B cells
12.40 Lunch
14.00 S. Hart (Edinburgh)
Regulation of macrophage phagocytosis of apoptotic neutrophils
14.40 B. Spruce (Dundee)
Regulation of phagocytosis by p53 and proenkephalin
15.20 V. Fadok (Denver)
Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells
16.00 Poster Session

Thursday 30 July

Hormone Group:
Expressing Membrane Proteins for Study

Organiser:
M. Wheatley (Birmingham)
Speakers:
09.40 M. Wheatley (Birmingham)
Chairman's introduction.
09.50 R. Patel (Leek, Holland)
Commercially available tools for expressing proteins
10.30 A. Rhodes (GlaxoWellcome)
Expression of recombinant proteins in mammalian cells.
11.15 Coffee
11.45 R. Grisshammer (Cambridge, UK)
Seven helix receptors: from over-expression towards structure determination.
12.30 Lunch
14.00 H. Reil�nder (Frankfurt)
Expression, characterisation and purification of G-protein-coupled receptors.
14.45 E. Landau (Basel)
Lipidic cubic phases as novel matrices for structural studies of membrane proteins
15.30 Close

Wednesday 29 July / Thursday 30 July

Industrial Biochemistry and Biotechnology Group:
Xenobiotic Pollution and Recovery by Natural Systems "The Biosphere Strikes Back"

Organiser:
D. Orwin (Luton)

Wednesday 29 July

Session 1: Behaviour of metals in natural systems

Chair:
P. Goldfarb (Surrey)
Speakers:
09.00 H. Eccles (British Nuclear Fuels)
Metal contaminated soil: is natural attenuation acceptable?
09.45 N. Brown (Birmingham)
Heavy metal resistance genes and proteins in bacteria
10.30 Coffee
11.00 S. Gray (Luton)
Fungi as potential bioremediation agents in soil contaminated with heavy or radioactive metals
11.45 N. Robinson (Newcastle)
Metals and genes in higher plants and cyanobacteria
12.30 Lunch

Session 2: Oestrogenic substances

Chair:
A. Wiseman (Surrey)
Speakers:
13.30 A. Wiseman (Surrey)
Biomolecular site-recognition in prediction of environmental oestrogen-mimicry
14.15 T. Ridgway (Surrey)
Removal of oestrogenic substances from the environment
15.00 M. Taylor (Leicester)
Impact of endocrine disruption on natural populations: key issues and identification of research priorities
15.45 P. Matthiessen (Centre for Environment, Fisheries and Aquaculture Science)
Endocrine disruption in the marine environment
16.30 Poster Session

Thursday 30 July

Session 3: Microbial degradation and remediation

Chair:
J. Lynch (Surrey)
Speakers:
09.00 C. Knowles (Oxford)
Biodegradation of metal cyanides by fungi
09.45 A. Baker (Sheffield)
Phytoremediation: a developing technology for the remediation and decontamination of metal-polluted soils and effluents
10.30 Coffee
11.00 N. Bruce (Cambridge, UK)
Microbial degradation of explosives
11.45 G. Robinson (Kent)
Factors influencing the microbial degradation of PCBs
12.30 I. Thompson (National Environmental Research Council)
Impact of pollution stress on soil microbial communities
13.15 Lunch

Session 4: Biomonitoring and assessment

Chair:
N. Robinson (Newcastle)
Speakers:
14.15 J. Lynch (Surrey)
Biomonitoring as a prelude to bioremediation
15.00 P. Goldfarb (Surrey)
Biomonitoring in the aquatic environment: use of molecular biomarkers
15.45 J. Mason (London)
Assessment of biodegrative potential and activity in a site contaminated with BTEX aromatic hydrocarbon pollutants: molecular approaches to environmental monitoring
16.30 Poster Session

Thursday 30 July/ Friday 31 July

Society Special Colloquium:
Polyamines: Specific Metabolic Regulators or Multifunctional Polycations?

Organiser:
H. Wallace (Aberdeen)

Thursday 30 July

Session 1
Polyamine Metabolism

Chair:
H. Wallace (Aberdeen)
Speakers:
09.00 H. Wallace (Aberdeen)
Welcome and opening remarks
09.05 L. Persson (Lund)
Regulation of Ornithine Decarboxylase
09.50 A. Pegg (Hershey)
Structure, function and regulation of S-adenosylmethionine decarboxylase
10.35 Coffee
Chair:
L. Persson (Lund)
Speakers:
11.00 D. Morgan (London)
Polyamine Oxidases - Enzymes of unknown function?
11.30 J. Mitchell (Illinois)
Anitzyme activity and the mitochondria
12.15 Lunch

Session 2
Polyamine Transport

Chair:
A. Pegg (Hershey)
Speakers:
13.30 P. Cullis (Leicester)
Chemical highlights in polyamine transport
14.05 H. Wallace (Aberdeen)
Regulation of polyamine acetylation and efflux in human cancer cells
14.40 A. Michael (Norwich)
Regulation of polyamine transport and biosynthesis in yeast
Chair:
J. Mitchell (Illinois)
15.25 Poster Discussion

Friday 31 July

Session 3
Physiology and Pathology of Polyamines

Chair:
E. Hollta (Helsinki)
Speakers:
08.50 M. Ariyanayagam (Dundee)
Diamine auxotrophy in a eukaryotic parasite
09.25 F. Muskiet (Groningen)
Cell synchronisation studies
10.00 Poster Session
11.00 S. Bardocz (Aberdeen)
Polyamines in reproduction
11.35 Poster Discussion
12.35 Lunch

Session 4
Polyamine Inhibitors and Cytotoxicity

Chair:
F. Muskiet (Gronigen)
Speakers:
14.00 D. Kramer (Buffalo)
Polyamine and polyamine analogue-induced perturbations of cell cycle control
14.35 R. Scott (Aberdeen)
Inhibition of voltage-activated potassium currents in cultured sensory neurones by the polyamine spider toxin Argiotoxin-636 may involve a polyamine transporter and an intracellular site of action
15.10 E. Holtta (Helsinki)
Do polyamines regulate cell transformation, invasion and angiogenesis?
Chair:
D. Morgan (London)
15.45 Poster Discussion
16.30 End

Trade Exhibition

There was a Trade Exhibition at this meeting
For further information contact:
The Meetings Office
Biochemical Society
59 Portland Place
London W1B 1QW
Tel: 020 7580 3481
Fax: 020 7637 7626
e-mail: [email protected]