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Meeting No 665, University of Southampton, 31 March - 2 April 1998



The Colworth Medal Lecture

Given by Dr David Barford

The Zeneca Award Lecture

Given by Professor Steve Homans
Wednesday 1 April/ Thursday 2 April

Host Colloquium
Structure and Mechanism of Enzymes

(In recognition of the contribution by Professor Muhummad Akhtar on his retirement)
Organiser:
P. Shoolingin-Jordan (Southampton)
Wednesday 1 April
Speakers:
09.30 P. Shoolingin-Jordan (Southampton)
Introduction: Structure and mechanism of enzymes in the biosynthesis of the tetrapyrrole macrocycle
10.20 Coffee
10.45 P. Leadlay (Cambridge)
The structure and function of adenosylcobalamin-dependent methylmaloyl-CoA mutase
11.35 R. Perham (Cambridge)
Swinging arms in multifunctional enzymes and the specificity of post-translational modification
12.25 Lunch
14.00 I. Scott (Texas)
How vitamin B12 is synthesized without oxygen: a comparison of the aerobic and anaerobic pathways to corrins
14.50 R. Baxter (Edinburgh)
Structure and mechanism of enzymes in the biotin biosynthesis pathway
15.40 D. Arigoni (Zurich)
Thursday 2 April
Speakers:
9.15 P. Frey (Wisconsin)
S-Adenosylmethionine: a poor man's coenzyme B12?
10.00 Poster Session
11.00 C. Abell (Cambridge)
Enzymes that use Schiff-base mechanisms
11.50 D. Gani (St Andrews)
Mechanism and stereochemistry of pyridoxal 5'-phosphate-dependent serine transhydroxymethyltransferase and decarboxylases
12.40 Lunch
13.40 J. Baldwin (Oxford)
Structure and mechanism of isopenicillin synthase
14.30 G. Petsko (Brandeis)
The complete catalytic cycle of cytochrome P450 at atomic resolution
15.20 M. Akhtar (Southampton)
Mechanism of oxygen activation in chemistry and biology

Tuesday 31 March/Wednesday 1 April

Bioenergetics Group
The Diversity of Bacterial Redox Proteins

Sponsors:
Belle Technology
Zeneca Lifescience Molecules
Organisers:
J. Jackson (Birmingham)
D. Richardson (East Anglia)
Tuesday 31 March
Speakers:
9.15 A. Hooper (Minnesota)
Redox proteins of the nitrifying bacteria
10.00 S. Ferguson (Oxford)
Cytochrome cd1: a haem enzyme of the nitrogen cycle
10.45 Coffee
11.15 A. McEwan (Brisbane)
Structural and spectroscopic studies of dimethylsulphoxide reductase: what have they revealed about catalysis in oxomolybdenum enzymes?
12.00 G. Butland (East Anglia)
Nitric oxide reductase
12.20 Lunch
13.40 J. Fontecilla Camps (Grenoble)
Structural studies on hydrogenases
14.25 S. Gupta (Birmingham)
Transhydrogenase
14.45 D. Richardson (East Anglia)
The redox proteins of bacterial heterotrophic nitrification and aerobic denitrification
15.20 D. Skibinski (Sheffield)
Characterisation of a putative proton translocating formate hydrogen lyase system
15.40 P. Little
Sulphur oxidation in photosynthetic bacteria
16.00 End

Wednesday 1 April

Speakers:
9.15 L. Hederstedt (Lund)
The membrane-integral domain of succinate-quinone reductases: a secretive haem-containing domain
10.00 C. Anthony (Southampton)
Quinoprotein dehydrogenases
10.45 Coffee
11.15 G. Reid (Edinburgh)
Structure and function of the soluble fumarate reductase from Shewanella putrefaciens
12.00 S. Mayer
High resolution structural studies on nitrogenase
12.20 Lunch
14.00 R. Thauer (Marburg)
Structure and function of methyl-coenzyme M reductase from methanogenic Archaea
14.45 D. Craig
Structure and mechanism of bacterial morphinone reductase
15.05 M. Jones (Sheffield)
Multiple pathways for light energy transduction in the bacterial reaction centre
15.40 I. Muhiuddin
Bacterial type I
16.00 End

Tuesday 31 March

Education Group
Biochemistry in the Medical Curriculum Revisited

Organisers:
H. Thomas (London)
B. Moreland (London)
Speakers:
9.30 Chairman's Introduction
9.40 B. Moreland (London) & H. Thomas (London)
Current approaches to biochemistry teaching in the medical curriculum: a survey of medical schools in the UK
10.20 K. Burdett (Manchester)
Four years experience of problem-based learning at Manchester
11.00 - 11.30 COFFEE
11.30 R. Jones (London)
Identifying a core curriculum for medicine
12.50 - 14.00 LUNCH
14.00 D. Begley (London)
Introduction to special study modules (SSM) in the medical curriculum followed by a round table discussion on core curriculum and SSM design

Tuesday 31 March/Wednesday 1 April

Lipid Group
The Molecular Structure of Phospholipids and the Regulation of Cell Function

Sponsors:
Sigma/ Aldrich Company
British Technology Group
Celltech Therapeutics
Yamanouchi Research Institute
Micromass (UK)
Pharmacia and Upjohn
Organisers:
A. Postle (Southampton)
D. Wilton (Southampton)

Tuesday 31 March

Speakers:
9.00 D. Vance (Edmonton)
Why has phosphatidylethanolamine N-methyltransferase survived during evolution?
9.45 M. Gelb (Seattle)
The interfacial enzymology of secreted phospholipase A2: scooting, hopping, loosening, structure determination and heparin binding
10.30 Coffee
11.00 R. Gross (St Louis)
The physiological significance and regulation of iPLA2
11.45 A. Borsch-Haubold (Oxford)
Regulation of cytosolic PLA2 by phosphorylation
12.30 Lunch
13.15 M. Wakelam (Birmingham)
Lipid structural specificity of phospholipase D-linked signalling
14.30 S. James (Stockholm)
The structure of phospholipase C isoforms and the regulation of phosphoinositide hydrolysis
15.15 F. Cooke (London)
Phosphatidylinositol (3,5) bisphosphate: a new signalling molecule
16.00 Poster Session

Wednesday 1 April

Speakers:
9.00 T. Lee (Southampton)
The effects of phospholipid structure on the function of a calcium pump
9.45 N. Salem (Bethesda)
Why is docosahexaenoic acid (C22:6n-3) essential for nervous system function?
10.30 K. Resch (Hanover)
The role of lysophosphatide acyltransferase and protein kinase isoforms in the regulation of lymphocyte responses
11.15 Coffee
11.45 K. Wirtz (Utrecht)
From non-specific lipid transfer to peroxisomal fatty acyl CoA-binding protein
12.30 D. Wilton (Southampton)
Anionic phospholipids and regulation of cell function
13.15 Lunch/ End

Thursday 2 April

Membrane Group
Membrane protein structure: the domain approach

British Biophysical Society Colloquium on Membranes
Organiser:
A. Lee (Southampton)
Speakers:
8.45 M. Sansom (Oxford)
Modelling the packing of transmembrane helices
9.30 M. Tanner (Bristol)
NMR studies of transmembrane helices
10.00 Poster Session
11.00 P. Yeagle (Connecticut)
NMR studies of cytoplasmic loops of G-protein receptors.
11.45 Coffee
11.45 G. Robillard (Groningen)
PEP-dependent phosphotransferase domains
12.30 R. Cornell (British Columbia)
Membrane-binding region of CTP: phosphocholine cytidylyltransferase (an extrinsic membrane protein)
13.15 Lunch
14.15 T. Blundell (Cambridge)
Growth factor receptor ectodomains: structural studies
15.00 I. Campbell (Oxford)
A domain approach to membrane proteins
15.45 R. Liddington (Leicester)
Integrin Domains
16.30 Close

Wednesday 1 April/Thursday 2 April

Nucleic Acids and Molecular Biology Group
Cytokine and Growth factor regulation of gene expression

Organisers:
K. Lillycrop (Southampton)
B. Connolly (Newcastle)
S. Jackson (Cambridge)
H. Hurst (London)

Wednesday 1 April

Session 1 - Cytokine and Growth Factor Signalling
Speakers:
9.00 R. Davis (Massachusetts)
Signal transduction by stress-activated MAP kinases
9.45 I. Kerr (London)
Jaks, Stats and signal transduction in response to the interferons and other cytokines
10.30 Coffee
11.00 S. Goodbourn (London)
 
11.45 N. Perkins (Dundee)
Regulation of Nf-kappaB and p53 transactivation by p300/CBP
12.30 Lunch
Session 2 - Transcriptional control of cell proliferation
Speakers:
14.00 A. Sharrocks (Newcastle)
Regulation of ETS domain transcription factor activity by MAP kinases
14.45 P. Shaw (Nottingham)
Modulation of transcriptional responses to proliferative signals
15.30 D. Gillespie (Glasgow)
Role of jun and SAPK / JNK in cell cycle control
16.15 Poster Session

Thursday 2 April

Session 3 - Transcriptional control of differentiation/development
Speakers:
8.45 T. Kouzarides (Cambridge)
Regulation of transcription by histone acetyltransferases
9.30 C. Hill (London)
Cytokine and growth factor regulation of gene expression
10.00 Poster Session
11.00 T. Wirth (Germany)
Transcriptional regulation in lymphocyte differentiation and activation
11.45 D. Latchman (London)
Control of neuronal differentiation and apoptosis by Bm-3 POU family transcriptional factors

Tuesday 31March

Techniques Group
Modelling and Membrane Proteins

British Biophysical Society Colloquium on Membranes
Organiser:
T. Watts (Oxford)
Speakers:
09.00 P. Adams (Yale)
Predicting the structure of helical transmembrane proteins by a combination of computational searching and experimental mutagenesis
09.40 A. Elofsson (Huddinge)
Analysis of helical transmembrane proteins.
10.20 D. Jones (Warwick)
Predicting the topology and structure of integral membrane proteins
11.00 Coffee
11.20 M. Sansom (Oxford)
Viral ion channels: models and simulations
12.00 J. Findlay (Leeds)
Towards an understanding of the structure and mechanism of action of the membrane sector of the vacuolar H±ATPase as revealed by protein chemistry
12.40 Lunch
13.10 H. Berendsen (Groningen)
Molecular dynamics simulations of membranes, porins and membrane peptides.
13.50 C. Dempsey (Bristol)
Combining dynamics simulations and amide exchange analysis to establish intrinsic helical properties in membrane polypeptides
14.30 M. Sutcliffe (Leicester)
Three-dimensional models of glutamate receptors
15.10 T. Schirmer (Basel)
Crystal structure analysis of transmembrane channels: from general porins to maltoporin.
15.50 R. Hubbard (York)
Low resolution modelling of transmembrane proteins - making the most of available experimental data
16.30 Close

Tuesday 31 March/Wednesday 1 April

Protein and Peptide Science Group
Suspect Proteins in Neurodegeneration

Tuesday 31 March
Chair:
9.00 B. Austen (London)
Welcome and introductory remarks
Speakers:
9.10 D. Allsop (SmithKline Beecham)
Fibrillogenesis of -amyloid
9.50 V. Belloti (Pavio)
Amyloid fibrillisation of lysozyme variants
10.30 Coffee
11.00 P. Lansbury (Boston)
Seeded protein polymerisation in Alzheimer's disease and Parkinson's disease
11.40 C. Norstedt (Stockholm)
Inhibitors of -amyloid fibril formation
12.20 Lunch
13.30 M. Goedert (Cambridge)
Intra-neuronal filamentous deposits in Alzheimer's and Parkinsons
14.20 G. Bates (London)
CAG/ polyglutamine expansion
15.00 J. de Belleroche (London)
Potential pathogenic mechanisms involving superoxide dismutase
16.00 Poster Session
Wednesday 1 April
Chair:
G. Roberts (Cambridge)
Speakers:
9.00 J. Hope (Newbury)
In vitro analysis of mammalian PrP protein
9.40 M. Baldwin (San Francisco)
Three dimensional structure of PrP - implications for prion disease
10.20 Coffee
11.00 S. Lindquist (Chicago)
The effects of chaperones on yeast and mammalian 'prion' proteins
11.40 E. Karren (SmithKline Beecham)
Presenilins - in search of functionality
12.20 Lunch
13.30 C. Miller (London)
Amyloid precursor protein: binding proteins and function
14.10 B. Austen (London)
Characterisation of -secretase
14.50 D. Sirinathsinghji (Merck, Sharpe & Dohme)
Transgenic Models of Alzheimer's Disease



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