University College, Cork, 7 - 9 September 1999
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- Meeting programme
- Meeting timetable
- General information
Wednesday 8 September/Thursday 9 September
Annual Symposium/Neuroscience Group Colloquium
Neuronal Signal Transduction and Alzheimer's Disease
Genetic and neurochemical approaches have helped to identify key molecules involved in the pathogenesis of Alzheimer's disease which include: the amyloid precursor protein (APP) and its proteolytic fragments particularly the -amyloid peptide, the microtubular-associated protein tau, the presenilins and apolipoprotein E. Recent analysis of research into the function of these diverse molecules shows they converge to affect and be affected by neuronal signal transduction pathways, ultimately influencing neuronal cell function, development and survival. The annual symposium brings together key researchers to focus upon these signal transduction pathways in Alzheimer's disease. It has become evident that increased attention to this research area will present pathological pathways and treatment strategies for Alzheimer's disease, while also assisting in the understanding of other related slowly progressive and irreversible neurodegenerative disorders.
- Sponsors:
- Elan Corporation (Ireland)
- Novartis (Ireland) Ltd
- Pfizer (Ireland) Ltd.
- Organizers:
- C. O'Neill (Cork)
- B. Anderton (London)
Wednesday 8 September
- Chair:
- B. Anderton (London)
- Speakers:
- 09.05 D. Allsop (Lancaster)
- Modulation of -amyloid production and fibrillization
- 09.40 S. Yan (Columbia)
- Cellular targets for the amyloid- peptide
- 10.15 K. Breen (Dundee)
- Post-translational processing of APP
- 10.50 Coffee
- 11.15 R. Neve (Harvard)
- Dysfunction in APP modulation of cell cycle protein activity: one cause of the neurodegeneration apparent in Alzheimer's disease
- 11.50 J. Hardy (Jacksonville)
- Genetics of dementia: from amyloids and presenilin to tau and synucleins
- 12.25 I. Lieberburg (Elan Pharmaceuticals, San Francisco)
- A novel therapeutic vaccine for Alzheimer's disease
- Special Guest Lecture sponsored by Elan Corporation Ireland
- 12.50 Lunch
- 14.00 P. Fraser (Toronto)
- Presenilin function: connections to Alzheimer's disease and signal transduction
- 14.30 M. Goedert (Cambridge)
- Tau mutations in FTDP-17 and their relevance for Alzheimer's disease
- 15.00 B. Anderton (London)
- Sites of phosphorylation in tau and factors affecting their regulation
- 15.30 J.-P. Brion (Brussels)
- Tau protein phosphorylation in Alzheimer's disease
- 16.00 Poster Session
- 17.00 EMBO Lecture
Thursday 9 September
- Chair:
- J. Hardy (Jacksonville)
- Speakers:
- 09.00 W. Strittmatter (North Carolina)
- Apolipoprotein E and Alzheimer's disease
- 09.35 S. Lovestone (London)
- ApoE and Alzheimer's disease: is tau the link?
- 10.10 T. Ohm (Berlin)
- ApoE and -amyloid: signals and effects
- 10.45 Coffee
- 11.15 R. Nitsch (Hamburg)
- Regulation of gene expression by muscarinic acetylcholine receptors: relevance to Alzheimer's disease
- 11.50 R. Cowburn (Stockholm)
- Receptor G-protein signalling in Alzheimer's disease
- 12.25 C. O'Neill (Cork)
- Dysfunctional ryanodine-receptor, calcium-release channels in Alzheimer's disease
- 13.00 Lunch
- Chair:
- R. Neve (Harvard)
- 14.00 J. Barnes (Glaxo Wellcome)
- Oxidation signalling and inflammatory pathways in Alzheimer's disease
- 14.35 D.Gary (Kentucky)
- Par-4, endoplasmic reticulum dysfunction and synaptic apoptosis in Alzheimer's disease
- 15.10 F. Van Leuven (Leuven)
- Modelling Alzheimer's disease in transgenic mice is it possible?
- 15.45 K. Duff (New York)
- Transgenic mouse models of Alzheimer's disease: phenotype and mechanisms of pathogenesis
- 16.20 Close
- For further information contact:
- The Meetings Office
- Biochemical Society
- 59 Portland Place
- London W1B 1QW
- Tel: 020 7580 3481
- Fax: 020 7637 7626
- e-mail: [email protected]
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The information on these pages is the most accurate available to date; however, changes do occur from time to time and you should contact the Society's Meetings Office for confirmation of the programme.
Registration forms for all the meetings listed on these pages are printed in The Biochemist or are available from the Biochemical Society's Meetings Office on request (e-mail: [email protected]).
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