University College, Cork, 7 - 9 September 1999

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Meeting programme
Meeting timetable
General information

Wednesday 8 September/Thursday 9 September

Annual Symposium/Neuroscience Group Colloquium
Neuronal Signal Transduction and Alzheimer's Disease

Genetic and neurochemical approaches have helped to identify key molecules involved in the pathogenesis of Alzheimer's disease which include: the amyloid precursor protein (APP) and its proteolytic fragments particularly the -amyloid peptide, the microtubular-associated protein tau, the presenilins and apolipoprotein E. Recent analysis of research into the function of these diverse molecules shows they converge to affect and be affected by neuronal signal transduction pathways, ultimately influencing neuronal cell function, development and survival. The annual symposium brings together key researchers to focus upon these signal transduction pathways in Alzheimer's disease. It has become evident that increased attention to this research area will present pathological pathways and treatment strategies for Alzheimer's disease, while also assisting in the understanding of other related slowly progressive and irreversible neurodegenerative disorders.
Sponsors:
Elan Corporation (Ireland)
Novartis (Ireland) Ltd
Pfizer (Ireland) Ltd.
Organizers:
C. O'Neill (Cork)
B. Anderton (London)

Wednesday 8 September

Chair:
B. Anderton (London)
Speakers:
09.05 D. Allsop (Lancaster)
Modulation of -amyloid production and fibrillization
09.40 S. Yan (Columbia)
Cellular targets for the amyloid- peptide
10.15 K. Breen (Dundee)
Post-translational processing of APP
10.50 Coffee
11.15 R. Neve (Harvard)
Dysfunction in APP modulation of cell cycle protein activity: one cause of the neurodegeneration apparent in Alzheimer's disease
11.50 J. Hardy (Jacksonville)
Genetics of dementia: from amyloids and presenilin to tau and synucleins
12.25 I. Lieberburg (Elan Pharmaceuticals, San Francisco)
A novel therapeutic vaccine for Alzheimer's disease
Special Guest Lecture sponsored by Elan Corporation Ireland
12.50 Lunch
14.00 P. Fraser (Toronto)
Presenilin function: connections to Alzheimer's disease and signal transduction
14.30 M. Goedert (Cambridge)
Tau mutations in FTDP-17 and their relevance for Alzheimer's disease
15.00 B. Anderton (London)
Sites of phosphorylation in tau and factors affecting their regulation
15.30 J.-P. Brion (Brussels)
Tau protein phosphorylation in Alzheimer's disease
16.00 Poster Session
17.00 EMBO Lecture

Thursday 9 September

Chair:
J. Hardy (Jacksonville)
Speakers:
09.00 W. Strittmatter (North Carolina)
Apolipoprotein E and Alzheimer's disease
09.35 S. Lovestone (London)
ApoE and Alzheimer's disease: is tau the link?
10.10 T. Ohm (Berlin)
ApoE and -amyloid: signals and effects
10.45 Coffee
11.15 R. Nitsch (Hamburg)
Regulation of gene expression by muscarinic acetylcholine receptors: relevance to Alzheimer's disease
11.50 R. Cowburn (Stockholm)
Receptor G-protein signalling in Alzheimer's disease
12.25 C. O'Neill (Cork)
Dysfunctional ryanodine-receptor, calcium-release channels in Alzheimer's disease
13.00 Lunch
Chair:
R. Neve (Harvard)
14.00 J. Barnes (Glaxo Wellcome)
Oxidation signalling and inflammatory pathways in Alzheimer's disease
14.35 D.Gary (Kentucky)
Par-4, endoplasmic reticulum dysfunction and synaptic apoptosis in Alzheimer's disease
15.10 F. Van Leuven (Leuven)
Modelling Alzheimer's disease in transgenic mice – is it possible?
15.45 K. Duff (New York)
Transgenic mouse models of Alzheimer's disease: phenotype and mechanisms of pathogenesis
16.20 Close

For further information contact:
The Meetings Office
Biochemical Society
59 Portland Place
London W1B 1QW
Tel: 020 7580 3481
Fax: 020 7637 7626
e-mail: [email protected]

The information on these pages is the most accurate available to date; however, changes do occur from time to time and you should contact the Society's Meetings Office for confirmation of the programme.

Registration forms for all the meetings listed on these pages are printed in The Biochemist or are available from the Biochemical Society's Meetings Office on request
(e-mail: [email protected]).