Meeting No 663, University College Galway, 3 - 5 September 1997

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• Molecular & Cellular Biology of the Bone
• Atherosclerosis, Hypertension and Thrombosis
• Phage Display of Proteins and Peptides
• Recombinant Antibodies and Receptors as Reagents and Drugs
• Royal Irish Academy Lecture
• Pre-Doctoral Meeting
• Biochemical Aspects of Aggression and Depression

Host/Hormone Group Colloquium
Molecular & Cellular Biology of the Bone

Co-ordinators:

P. Hauschka (Boston)

H. Loughrey (Galway)

G. Williams (London)

Sponsors:

BioResearch Ireland

Trinity Biotech

9.00am Prof. Pat Fottrell, The President, UCG.

Welcome address

9.10am Prof. J. Triffitt (England)

"Osteogenesis"

9.55am Dr. Michael Grant (Manchester, UK)

"Molecular Biology of Endochondral Ossification"

11.20 am Jane Lian (Worcester, MA, USA)

"Osteoblast differentiation and gene expression"

12.05 pm Dr. David Roodman (San Antonio, TX,USA)

"Osteoclast differentiation and activity"

1.45 pm Dr. A. Zambonin Zallone (Italy)

"Osteoclast-matrix interaction in recruitment of precursors and in bone resorption"

2.30 pm Dr. Graham Rusell (Sheffield, UK)

"Control and bone cell communication and activity"

4.15 pm Dr. G. Gross (Germany)

"Bone Morphogenetic Protein (BMP) Mediated Function and Signaling in Mesenchymal Differentiation Systems"

5.00 pm Dr. M-J. Oursler (Mayo Clinic, USA)

"Steroid hormone action"

9.00am Dr. H. Loughrey (UCG, Galway)

"Progesterone receptor expression in Human Osteoblasts"

9.40am Dr. P. Ducy (Houston, USA)

"Genetic analysis of skeletal gla protein function"

10.20am Dr. M. Power (UCG, Galway)

"Bone markers"

11.30pm Prof. P. Hauschka (Boston, USA)

"Nitric oxide as an intracellular signal"

12.15pm Dr. T. Skerry (UK)

"Regulation of gene expression in bone by mechanical loading and the role of glutamate receptors in the skeleton"

Atherosclerosis, hypertension and thrombosis; Biochemistry, genetics and interrelationship of these complex multifactorial diseases.

Sponsors:

European Molecular Biology Organization

Co-ordinator:

T. Smith (Galway)

9.30 am Prof. Gordon Ferns (Surrey, UK)

"Atherosclerosis- the cellular events and their modulation"

10.15 am Prof. James Scott (Oxford, UK)

"Biochemistry and molecular genetics of atherogenic lipoprotein biosynthesis"

11.30 am Dr. Steve Humphries (London, UK)

"Predisposition genes, high-risk environments and coronary artery diseases (CAD)"

12.15 am Dr. Nobuyo Maeda (North Carolina, USA)

"Testing risk factors for atherosclerosis in mice"

2.00 pm Dr. Ian Graham (Meath Hospital Dublin)

"Homocysteine: Genetic, environmental aspects and risk"

3.45 pm Prof. Steve Whitehead (TCD)

"Genetic defects in enzymes controlling homocysteine concentrations: Emerging risk factors in cardiovascular disease"

4.30 pm Prof. Oliver Smithies (Univ. of North Carolina)

"A mouse view of hypertension"

Phage Display of Proteins and Peptides

Co-ordinator:

J. McCafferty

09.00am John McCafferty (Cambridge, UK)

Introduction

09.05am Philippe Holliger (Cambridge, UK)

Gene 3 protein and phage infection.

09.45am Stefania Spada (Switzerland)

Selectively Infective Phages.

10.30-11.00am Coffee

11.00am Andrew Bradbury (Italy)

Towards selection by infection. Augmenting the host range of phage fd

11.45 Ian Tomlinson (Cambridge, UK)

Reproducing human antibody diversity in a test tube

12.30-1.30pm Lunch

1.30pm Soeren Buus (Denmark)

Selection of antibodies with antigen specific MHC restricted specificity of T cells

2.15pm Jane Osbourn (Cambridge, UK)

Ligand directed cell surface selections

3.00-4.00pm Posters

4.00pm Laurent Jespers (Belgium)

Functional epitope mapping by negative selection of phage displayed randomised protein libraries

4.45pm Short Presentations from selected posters

2.00pm To be determined

2.45pm Brian Kay (USA)

Defining the specificity of SH3 domains with Random Peptide Libraries

3.00-4.00pm Coffee

4.00pm Ian Jones (Oxford, UK)

Alternative display technologies; Baculovirus display

4.45pm Mark Chadwick (Cambridge, UK)

Alternative display technologies; Retroviral Display

Biochemical Immunology Group/Irish Area Section
Recombinant Antibodies and Receptors as Reagents and Drugs

Co-ordinators:

J. Gosling (Galway)

D. Reen (Dublin)

B. Wisdom (Belfast)

K. Mills (Ireland)

9.00 am D. Donald (North Carolina, USA)

"Recombinant Cell Bioassay"

9.45 am A. Griffiths (Cambridge, UK))

"Building and exploiting large antibody repertoires"

11.00 am Irish Immunological Society Special Lecture P.Holt (Australia)

"Regulation of the induction and expression of T-cell immunity at respiratory mucosal surfaces"

12.00 pm A Pluckthun (Zurich, Switzerland)

"Improving antibodies by engineering: stability, bacterial production and multivalency"

1.45 pm G. Whitlam (Leicester, UK)

"Plantibodies: Recombinant antibodies expressed in plants"

2.25 pm M.J. Glennie (Southhampton, UK)

"Application of recombinant antibodies to the treatment of cancer: the role of cell signalling in antibody-mediated killing"

4.05 pm D. Burton (La Jolla, USA)

"Recombinant antibodies and infectious disease"

4.45 pm B.P. Morgan (Cardiff, UK)

"Therapeutic uses of recombinant complement receptors"

Royal Irish Academy Lecture

5.30pm Dr. Gerry O'Cuinn (Galway, Ireland)

"Metabolism of peptides by guinea pig brain cells"

Pre-Doctoral Meeting

9.00 am Grace Creedon Royal College of Surgeons, Dublin.

Studies on factors regulating lipoprotein lipase in monocytic cells

9.20 am Orla O'Donovan Biochemistry Department, UCG

Roles of growth hormone in peptide amidation.

9.40 am Suzie Coughlan Biochemistry Department, UCD

Are salt bridge networks the secret of protein thermostability?

10.00 am Mark Meighan School of Biology and Biochemistry, QUB

Single Chain Variable Fragment Antibodies from a Phage Display Library

10.50 am Sinead Walsh Biochemistry Department, TCD

Structure and function of glutathione-S-transferase Pi

11.10 am Roz McDonnell Biochemistry Department, UCD

Proteolysis as a regulator of cell cycle progression.

11.30 am Mary Kelliher Biochemistry Department, UCC

Loss of ryanodine receptor channel proteins in the Alzheimer's disease brain

2.00 pm Myra Conway Biochemistry Department, UCG

Pyridinoline cross-links; markers of bone resorption.

2.20 pm Cara Baker Biochemistry Department, TCD

Heterologous expression of the serotonin transporter

2.40 pm Paul Forsythe School of Biology and Biochemistry, QUB

Structure-Activity Relationships of Mast Cell Degranulating Peptides'

4.00 pm Pat Lynch Biochemistry Department, UCC

Mutation screening of the ryanodine receptor in malignant hyperthermia and central core disease.

4.20 pm Kevin Joyce

School of Biomedical Sciences, Coleraine Cellular effects of low intensity laser irradiation.

Molecular & Cellular Pharmacology Group/Irish Area Section
Biochemical Aspects of Aggression and Depression

Sponsors:

SmithKline Beecham Pharmaceuticals

Chairpersons:

J. Donlon (Ireland)

K. Tipton (Dublin)

9.00am John Kelly and Brian Leonard (UCG, Galway)

"Introduction-Models and responses in depression and aggression"

9.45am Clive Williams (TCD, Dublin)

"5-HT transporters-properties and expression"

10.30am D. Middlemiss (UK)

"5-HT receptors and depression"

11.45am H. Brunner (The Netherlands)

"Monoamine oxidaes and aggression"

12.30pm D. Nutt (UK)

"Imidazoline receptors, monoamine oxidase and depression"

1.15-2.15pm Lunch

2.15-3.15pm Posters

3.15pm M. Gerlach (Germany)

"Aminergic systems in aggressive behaviour of normal individuals and depressive syndrome"

4.00pm T. Dinan (UK)

"Hormonal correlates of affective disorders"