University of Glasgow Meeting, 7-9 April 1999

Themed Meeting, centred around: "Complex Protein Assemblies as Molecular Machines"

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Meeting Programme

Regulation in Metabolism Group/ Membrane Group colloquium:
Phospholipids: regulators of membrane traffic and signalling

Sponsors:

Echelon Research Laboratories

Eli Lilly & Co

The Gatsby Charitable Foundation

Merck Sharpe & Dohme

Novartis

SmithKline Beecham

Unilever

Yamanouchi

Zeneca

Organisers:

S. Cockcroft (London)

P. Hawkins (Cambridge, UK)

Lipids as targetting devices

Chair:

B. Michell (Birmingham)

Speakers:

09.00 B. Michell (Birmingham)

Chair's Introduction

The Philip Godfrey Memorial Lecture

09.20 B. Hemmings (Basel)

PH domains in cell signalling

09.50 T. Meyer (North Carolina)

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

10.30 Coffee

11.00 Society Medal Lecture

12.10 M. Lemmon (Philadelphia)

Structural bases for specific phosphoinositide binding by PH domains

12.50 Lunch

Cellular functions of PIP3

Chair:

P. Hawkins (Cambridge)

Speakers:

13.50 D. Alessi (Dundee)

Insulin signalling downstream of PI 3-kinase

14.30 D. Fruman (Harvard)

PI 3-kinase gene knockouts

15.10 S. Watton (London)

Localisation of Akt and 3' phosphoinositides

15.50 M. Wymann (Fribourg)

PI 3-kinase signalling - no lipids

16.30 Poster Session

17.30 Membrane Group Committee Meeting

18.15 Membrane Group AGM

Lipids in vesicle formation and consumption

Chair:

S. Cockcroft (London)

09.00 F. Wieland (Heidelberg)

Biogenesis of COP1-vesicles: proteins and mechanisms

09.40 W. Huttner (Heidelberg)

Lipid-protein interactions in the biogenesis of neurosecretory granules and vesicles

10.20 Coffee

11.00 Society Medal Lecture

12.10 N. Ktistakis (Cambridge, UK)

Intracellular transport and organelle morphology in cell lines with inducible overexpression of PLD1, or of a PLD1-derived anti-sense fragment

12.50 M. De Matteis (Chieti, Italy)

ARF regulates spectrin-skeleton assembly on the Golgi complex by stimulating PIP2 synthesis

13.40 Lunch and Regulation in Metabolism Group Committee Meeting

PIP2 functions

Chair:

W. Huttner (Heidelberg)

14.40 S. Cockcroft (London)

ARF-regulated phospholipase D in membrane traffic

15.20 G. Schiavo (London)

Phosphoinositides and neurotransmitter release

16.00 H. Yagisawa (Hyogo)

PLC-delta and related molecules

16.40 R. Irvine (Cambridge, UK)

The regulation of type II PIPkins (PI4P 5-kinases)

17.20 Poster Session

Cellular functions of PI3P in traffic

Chair:

B. Hemmings (Basel)

09.00 M. Clague (Liverpool)

Regulation of endosome fusion

09.40 H. Stenmark (Oslo)

EEAI, an effector for phosphatidylinositol 3-phosphate and the GTPase rab5 in endocytic membrane fusion

10.20 Poster Session

11.00 S. Ponnambalam (Dundee)

Lipid kinases and trans-Golgi network membrane dynamics

11.40 S. Dove (Birmingham)

Phosphatidylinositol 3,5-bisphopsphate: the biosynthesis and function of a "new" PtdInsP2 isomer

12.20 Lunch

PTDINSP2 isomer

Chair:

R. Irvine (Cambridge, UK)

Speakers:

13.30 J. Tavare (Bristol)

Regulation of vesicle and protein trafficking by insulin in living cells

14.10 G. Gould (Glasgow)

The role of phospholipid-derived signals in the control of membrane trafficking in insulin-sensitive cells

14.50 P. J. Cullen (Bristol)

PI 3-kinase effector molecules

15.30 P. Hawkins (Cambridge)

Searching for novel targets of PtdIns(3,4,5)P3 and PI(3,4)P₂