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Regulation in Metabolism Group

The Regulation in Metabolism Group exists to organize meetings which promote a better understanding of the regulation and control of biological processes at the biochemical level.  This encompasses diverse areas such as nutrient utilsation and energy conversions, cell signalling in health and disease and cell and protein structure and function.  As such our aims overlap with numerous other interest groups within the Society which is  reflected in the number of colloquia which we organize jointly with these other committees. From time to time we also hold symposia with other societies such as The Nutrition Society and The Physiological Society

Committee and AGM
Recent  and forthcoming colloquia:
Research Interests and Biographical Details of Committee Members
What we are about!
New Avenues of Research in Fatty Acid Oxidation and Ketone Body Metabolism: the scientific legacy of Derek Williamson

Committee members:

Mike Titheradge (Chair University of Sussex  E-mail:
David Tosh (Secretary) University of Bath E-mail:
Simon Eaton Institute of Child Health,  London. E-mail:
John Harwood University of Cardiff, Wales, E-mail:
David Fell Oxford Brookes University, E-mail:
Phill Hawkins The Babraham Institute, Cambridge E-mail:
Brendan Leighton Zeneca, Alderley Edge, E-mail:
Jennifer Rivett University of Bristol, E-mail:
Victor Zammit Hannah Research Institute, Ayr, Scotland E-mail:


The date for the 2001 AGM will be announced soon.

Recent and forthcoming colloquia

Insulin Action Bristol 2001 Contact

Metabolic Complexity and Channelling Colloquium - Dedicated to the Memory of Paul Srere York 2001- Contact or

Fatty Acid Oxidation & Ketone Body Metabolism Host Colloquium - Dedicated to the Memory of Dr Derek Williamson Sussex 19-21 December 2000 with Pre-doctoral Meeting, 18 December. Details about Publication of the Proceedings of this meeting.

Organisms, Organs, Cells and Organelles: in vivo and in vitro experimental systems (Joint with  Molecular Enzymology Group) Cork 7th-9th September 1999

Phospholipids: regulators of membrane traffic and signalling (Joint with Membrane Group) Glasgow 7th-9th April 1999

Endocrine Control of Perinatal Programming in Health and Disease (Joint with Hormone Group) Leicester 22nd-23rd September 1998

Modelling Metabolism (Joint with Education Group) Leicester 22nd-23rd September 1998

Pre- and post-partum nutrition and metabolism colloquium (joint with The Nutrition Society) Host Colloquium for the Biochemical Society, Reading 15th-17th December 1997

Research Interests and Biographical Details of Committee Members

Dr Phillip Hawkins is a Lecturer at the Babraham Institute, Cambridge. His research interests include: intracellular signalling pathways in mammalian cells; inositol phospholipids, inositol phosphates and the phosphoinositide 3-kinase (P13K) signalling pathway. The Babraham Institute, Babraham, Cambridge, CB2 4AT. Tel: 01223 496598 Fax: 01223 496043 E-mail:

Dr David Tosh is a Lecturer in the Department of Biology and Biochemistry at the University of Bath.  His research interests are currently centred on elucidating the cellular and molecular mechanisms underlying pancreas and liver development. School of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, Telephone: +44 1225 826532FAX: +44 1225 826449 or 826779 E-mail:

Dr Mike Titheradge is Senior Lecturer in the School of Biological Sciences, University of Sussex. His research interests are : Regulation of hepatic carbohydrate metabolism; liver metabolism in septic shock; nitric oxide and the liver. School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG. Tel. 01273 678742, Fax  01273 678433. Email:

Dr Simon Eaton is a Non-Clinical Lecturer in the Unit of Paediatric Surgery, Institute of Child Health, London. His research interests are: intramitochondrial control of beta-oxidation, development of beta-oxidation, and oxidative  metabolism in neonatal sepsis. Institute of Child Health, University College, 30 Guilford Street, London, WC1N 1EH. Telephone : +44 (0)20 79052158 Fax: +44 (0)20 7404 6181 E-mail:

Dr Victor Zammit is Senior Principal Research Scientist at the Hannah Research Institute, Ayr, Scotland. His Research Aims are: elucidation of the mechanisms through which the liver contributes different substrates for utilisation by peripheral tissues, including the partitioning of fatty acids between oxidation to ketone bodies and acylglyceride synthesis, and the involvement of different signal transduction systems in the control of these and the cholesterogenic pathway. Hannah Research Institute, Ayr, Scotland, KA6 5HL. Telephone +44 1292 674058, Fax +44 1292 674004 E-mail:

Prof. John Harwood is Head of the Environmental Biochemistry and Microbiology research group at the University of Cardiff. John Harwood has research interests on the regulation of metabolism of acyl lipids. These interests concentrate on plant lipids, especially the role of the environment in changing metabolism. However, environmental factors such as temperature, xenobiotics and heavy metals are being investigated in relation to other organisms. Medical topics include lung surfactant and infammatory responses. Regulation is being studied by flux control analysis of whole systems, at the enzyme level and in relation to changed gene expression. Cardiff School of Biosciences, PreClinical Building, Cardiff University, PO Box 911, Cardiff, Wales, CF1 3US. Telephone : +44 1222 874108, Fax: + 44 1222 874116 E-mail:

Dr Brendan Leighton is a Team Leader in the CardioVascular & GastroIntestinal Discovery Department at AstraZeneca.  His research interests include: understanding the mechanisms underlying the development of insulin resistance in skeletal muscle; the role of nitric oxide/cGMP in regulating carbohydrate metabolism in muscle; in vivo analysis of mechanisms of action of drugs that lower blood glucose concentrations. AstraZeneca Pharmaceuticals, 3S36, Mereside, Macclesfield, SK10 4TG, Telephone: +44 1625 515766  Fax: +44 1265 517738  E-mail:

Professor David Fell is Deputy Head of the School of Biological and Molecular Sciences at Oxford Brookes University. The unifying theme in his research is the attempt to understand the general principles governing the organization, regulation and control of metabolism. This involves the development and application of suitable theoretical tools: metabolic control analysis, computer simulation and other forms of algebraic and numerical analysis. Potential applications are the rational design of changes in metabolism (metabolic engineering) and improved understanding of how hormonal and environmental signals can cause large changes in specific metabolic processes with minimal other disruption to the cell. He is author of "Understanding the Control of Metabolism" published by Portland Press. School of Biological and Molecular Sciences, Oxford Brookes University, Headington, Oxford, OX3 0BP Telephone +44 (0)1865 483247 Fax: +44 (0)1865 484017

Dr. A. Jennifer Rivett is Reader in Biochemistry in the Department of Biochemistry, Univeristy of Bristol. Her research interests centre on proteasomes. Proteasomes are the major nonlysosomal proteolytic machinery of eukaryotic cells. They are found in the nucleus and in the cytoplasm and play a key role in the degradation of regulatory proteins (including cyclins and transcription factors). Department of Biochemistry, Univeristy of Bristol., University Walk, Bristol, BS8 1TD Tel: (0117) 928 8929 E-mail:

Details about Publication of the Proceedings of the Sussex Fatty Acid Oxidation & Ketone Body Metabolism Meeting.
We are intending to publish all the proceedings from the meeting, including the Pre-Doctoral day. Speakers from the main meeting will  be published as usual in  Biochemical Society Transactions. In addition, we are intending to publish all presenters of posters from both the main meeting and the predoctoral day and presenters of talks from the predoctoral day. The deadline for submission of manuscripts is 31st January 2001, please contact E-mail: if you would like further details.

What we are about! 

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